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\addcontentsline{toc}{chapter}{Acknowledgements}
\chapter*{Acknowledgements}
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Throughout the process of PhD study, research and writing this thesis, I have received a great deal of support and help. 
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I would like to thank my supervisors: Dr Declan Doyle, Prof Vincent O'Connor and Prof Lindy Holden-Dye, whose expertise, knowledge, enthusiasm and motivation was invaluable. Without your guidance this PhD would have been unachievable.
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I would like to acknowledge The Gerard Kerkut Charitable Trust for providing funding for this PhD project. 

I am also very grateful to Prof Robert Walker, Prof Nullin Divecha and Dr James Dillon for their insightful comments and encouraging words. 

My thanks go to Dr Alistair Bailey for his help with writing and formatting this thesis and for keeping me company throughout my studies. 

Thank you to all members of the worm-lab and the lab of Dr Declan Doyle for all the fun we have experienced together. In particular, I would like to thank Dr Ben Yarnall, Dr Fernando Calahorro and Dr Anna Crisford for your support and technical help.

I am grateful to my all my family members who always believed in me. 

Last but not least thank you to my partner, Damien Parsey for his continual emotional support, patience and understanding. I would not have made it without you.